UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure

Inclusion Criteria: 1. Patients with ACLF-which is characterized by acute hepatic insult manifesting as jaundice (serum total bilirubin ≥ 10×ULN umol/L) and coagulopathy (international normalized ratio≥ 1.5 or prothrombin activity \< 40%), complicated within 4 weeks by ascites and/or encephalopathy as determined by physical examination, in patients with previously diagnosed or undiagnosed chronic liver disease; 2. Positive serum hepatitis B surface antigen (HBsAg) for more than 6 months; 3. End-stage liver disease scores ranging from 17-30,; 4.18-65 years of age. Exclusion Criteria: 1. Serious complications within the previous 2 months (e.g. gastrointestinal bleeding, serious infection ); 2. Concomitant autoimmune disease; 3. Superinfection with other hepatitis viruses; 4. Important organ dysfunctions not due to liver disease or malignancies; 5. Pregnancy and lactation; 6. Liver tumor or nodules secondary to cirrhosis proven by ultrasound, computerized tomography (CT), or magnetic resonance (MR) imaging; 7. Bioartificial liver support therapy; 8. Previous liver transplantation.