Does Sedation Depth (as Evaluated by the Bispectral Index) Influence Dynamic Indices of Preload Dependence?

Centre Hospitalier Universitaire, Amiens45 enrolled

Overview

Dynamic indices of preload dependence (such as stroke volume variability -SVV , pulse pressure variability - PPV and plethysmograph variability index - PVI ) are reportedly predictive of the response to vascular filling in sedated, mechanically ventilated patients. However, the influence of the sedation depth on these dynamic indices has never been evaluated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thoracic Surgery

Interventions

transthoracic echocardiographyDEVICE

recording of data on cardiac output measured non-invasively by transthoracic echocardiography, including the SVV

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All sedated, intubated, mechanically ventilated adult (over-18) patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI) * Good echogenicity * Social security coverage Exclusion Criteria: * Pregnancy, legal guardianship * Subjects with black skin (a known technical limitation of plethysmography) * Cardiac arrhythmia * Sepsis * Poor echogenicity

Locations (1)

CHU Amiens

Amiens, France

Outcomes

Primary Outcomes

Values of the dynamic indices (SVV, PPV and PVI) at different sedation levels (as evaluated by the BIS)

Time frame: Day 0

Secondary Outcomes

The proportion of patients that change their preload dependence status during a change in sedation depth (as evaluated by the BIS).

Time frame: Day 0

Data from ClinicalTrials.gov

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