Prognostic Value of Adipokine Levels of Patients With Chronic Heart Failure

Chongqing Medical University98 enrolled

Overview

The purpose of this study is to determine whether expressions of adipokines can provide prognostic information concerning patients with chronic heart failure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Heart Failure

Eligibility

Sex: ALLMin age: 12 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are giving open chest surgical treatment with a history of chronic heart failure (NYHA II \~ IV) more than 6 months. * Patients from whom informed consent has been properly obtained in writing prior to start of the trial. Exclusion Criteria: * Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases,or any other malignancy. * Patients with a history of cardiomyopathy. * Patients with Chronic arrhythmia. * Pregnant women * Severe hepatic dysfunction or End-stage renal failure. * Uncontrolled hypertension.

Locations (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

All-cause mortality

Time frame: Change from Baseline at 3, 6 and 12 months

Secondary Outcomes

New York Heart Association (NYHA) Classification

Time frame: Week:4

re-hospitalization

Heart failure with re-hospitalization is documented by at least one of the following: worse exercise tolerance and respiratory distress with NYHA class III or IV symptoms, presence of pulmonary rales, or chest radiography showing pulmonary congestion, which needs an augmented decongestive regimen with oral or intravenous medications during an in-hospital stay.

Time frame: Change from Baseline at 3, 6 and 12 months

plasma brain natriuretic peptide (BNP) concentration

Time frame: Week:4

Cardiovascular death

Time frame: Change from Baseline at 3, 6 and 12 months

Cardiac transplantation

Time frame: Change from Baseline at 3, 6 and 12 months

Data from ClinicalTrials.gov

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