Tolerance of Myocardium to Ischemia Injury

University Hospital, Lille88 enrolled

Overview

This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Reperfusion Injury Myocardial Ischemia

Interventions

cardiac surgery scheduled in the morningPROCEDURE

cardiac surgery scheduled in the morning

cardiac surgery scheduled in the afternoonPROCEDURE

cardiac surgery scheduled in the afternoon

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation * Patient in sinus rhythm at the time of surgery * Patient older than 18 * Patient able to understand the information and consent forms Exclusion Criteria: * Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug * left ventricle ejection fraction \< 40% * Pregnancy * Patient in emergency condition

Locations (1)

Lille University Hospital

Lille, France

Outcomes

Primary Outcomes

ischemia reperfusion injury in ex vivo conditions

measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion

Time frame: the day of the myocardial biopsy

Data from ClinicalTrials.gov

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