Lutonix or Inpact for tHE tReatment Of fEmeropopliteal Stenosis - Drug Coated Balloon

Inclusion Criteria: 1. Patient is willing and able to provide informed consent, willing and agrees to comply with regular follow up visits, testing, medication regimen compliance any another treatments deemed necessary for treatment of vascular disease. 2. Male or non-pregnant female 3. Age greater \>=18 years of age 4. Patients with moderate to severe claudication or ischemic rest pain as defined by Rutherford 2-4 class symptoms 5. \>=1 tibial run-off vessel at baseline 6. Angiographic criteria * \>=70% stenosis (via visual angiographic estimate in the superficial femoral artery and/or popliteal arteries as appropriate) * 4-7 mm vessel diameter * \<=15 cm for planned treatment segment length. * Planned treatment segments are to no further proximal than 1 cm from the bifurcation of the common femoral artery and no further distal than the 1 cm above the tibioperoneal trunk. * Lesions treated within the target vessel are either De Novo lesions or not previously stented restenotic segments of the superficial femoral artery and/or popliteal artery that are greater than 90 days from prior angioplasty procedure * If the target vessel was previously stented the treated lesion must be at least 3 cm from the previously placed stent * Lesion must be able to be treated with either drug coated balloon device based on the sizes specifications of both devices * Successful, uncomplicated crossing must be possible within the treated lesion either with or without a crossing device * Inflow artery must be free from significant occlusive disease (\< 50%) as confirmed by visual estimation by angiography otherwise the inflow artery must be treated beforehand. * At least 1 patent vessel outflow from the target vessel treated must be present by angiography Exclusion Criteria: 1. Unable to meet clinical criteria to have peripheral angioplasty and follow-up treatment (lab values and pregnancy test) 2. Contra-indicated to either drug coated balloon 3. \< 18 years of age at time of consent and/or index procedure 4. Pregnant or breastfeeding 5. In-stent restenosis within the target lesion 6. Previously stented target lesion/vessel. 7. Target lesion/vessel previously treated with drug-coated balloon \<12 months prior to randomization/enrollment. 8. Perforated vessel as evidenced by extravasation of contrast media prior to consent or enrollment. 9. Presence of other hemodynamically significant outflow lesions in the target limb requiring intervention \<=30 days of consent or randomization. 10. Presence of aneurysm in the target vessel. 11. Major amputation in the target limb. 12. Subjects who have undergone prior surgery of the superficial femoral artery/proximal popliteal artery in the target limb to treat atherosclerotic disease. 13. Use of atherectomy, laser or other debulking devices in the target limb superficial femoral artery/proximal popliteal artery during the index procedure. 14. Acute ischemia and/or acute thrombosis of the superficial femoral artery/proximal popliteal artery prior to consent or randomization. 15. Known hypersensitivity or contraindication to contrast dye that, in the opinion of the local investigator, cannot be adequately pre-medicated. 16. Known hypersensitivity/allergy to the investigational stent system or protocol related therapies. 17. On dialysis or on an immunosuppressant therapy. 18. Concomitant renal failure (including serum creatinine \>2.0 mg/dL.) 19. Occurrence of myocardial infarction or cerebrovascular accident \<=6 months prior to consent. 20. Platelet count \<80,000 mm3 or \>600,000 mm3 or history of bleeding diathesis. 21. Unstable angina pectoris at the time of consent or randomization. 22. Septicemia at the time of consent or randomization. 23. Moderate to severely calcified lesions.