The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.
Adiponectin (APN) is an abundant protein hormone derived from adipose tissue. It has been suggested to exert anti-inflammatory, antiatherogenic, and vascular protective. Subarachnoid hemorrhage (SAH) comprises about 5% of all strokes with high mortality and permanent disability rates. Although many patients survive from the initial hemorrhage or rebleeding, they suffered from long-term delayed neurological deficits (DNDs), including stroke, delayed cerebral ischemia, cognitive and neuropsychological abnormalities that seriously impact overall function and quality of life. Ruptured cerebral aneurysms are the most common cause of SAH. There is growing evidence supporting APN act as a predictive factor for SAH. The observational study will focus on the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage (aSAH).
Study Type
OBSERVATIONAL
Enrollment
100
Tandu Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China
RECRUITINGIncidence of cerebral vasospasm and delayed cerebral ischemia
Proved by clinical and radiologic evidence
Time frame: 30 days post SAH
Death
Time frame: 30 days post SAH
National institutes of health stroke scale (NIHSS) score
Assessing by senior neurosurgeons
Time frame: On discharge or 14 days (whichever occurs first) and 30 days post SAH
Modified Rankin scale (mRS)
By phone call following-up
Time frame: 30 days and 90days post SAH
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