Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm

Centre Hospitalier Universitaire, Amiens55 enrolled

Overview

Action slowing has been demonstrated in many diseases. Parkinson's disease (PD) and Huntington's disease (HD) are two neurodegenerative diseases affecting the basal ganglia, particularly the medial globus pallidus, and the clinical expression of these two diseases is characterized by a combination of motor and cognitive disorders, but with two opposing patterns of dysfunction. Action slowing has been demonstrated in both of these diseases and has been extensively studied in Parkinson's disease, suggesting a perceptive-cognitive origin. Far fewer studies have been conducted in Huntington's disease. However, all of these studies were performed with different methodologies in small cohorts and the value of the proposed study is to use a validated and standardized computerized mental chronometry paradigm, providing a better understanding of the mechanisms of action slowing in these two diseases and to more clearly define a disease-specific profile.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Parkinson Disease Huntington Disease

Interventions

SRT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Agreeing to participate in the study * French mother tongue * MMSE \> 20/30 * Specific to the MP and MH: * Parkinson's disease: * defined by the criteria of the UKPDSBB * stage 1 , 2 or 3 Hoehn and Yahr (ON) * age of onset of the disease known * brain MRI performed during follow-up * Huntington disease : * genetically defined (CAG \> 35) * weaning neuroleptic ( Tercian® and Solian® : 2 days; Haldol® : 5 days ; Tiapridal® and Xenazine : 1 day ; Zyprexa® : 4 days) * Early stage : Fahn and Shoulson I and II is a CFT score between 7 and 13 Exclusion Criteria: * Illiteracy, writing or reading difficulties * Visual perceptual auditory deficit or preventing reading, drawing, writing or understanding instructions * Visual hallucinations * Significant history may sound on cognition (unbalanced thyroid dysfunction, ischemic heart disease or embolic unstabilized or symptomatic, progressive neoplasia, chronic alcoholism weaned or not) * Current or previous neurological diseases other than MH or MP: ischemic cerebral vascular accident or bleeding, head injuries (loss of higher knowledge in 15 minutes), epilepsy requiring treatment. * Psychiatric disorders depression unless treated (stable treatment for 1 month) * Psychotropic treatment (except anxiolytic, antidepressant steady since 1 month) * Inability to achieve an autonomous operation without technical assistance over a distance of 20 meters. * Inability to stand without technical assistance for 30 seconds.

Outcomes

Primary Outcomes

SRT

simple reaction time ( SRT) defined as the fastest response time to a target stimulus ( phase "worst -off" at the Parkinson's patient )

Time frame: Day 0