Electrohaemodynamic Activity in Epileptic Children : Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis

Centre Hospitalier Universitaire, Amiens23 enrolled

Overview

Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci

This study is designed to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Epilepsy

Interventions

multimodal high-resolution EEG-NIRSDEVICE

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children between the ages of 6 and 18 years * with drug-refractory partial epilepsy, presenting interictal spikes on standard EEG recordings. Exclusion Criteria: * Children with a serious congenital malformation. * Refusal from one of the parents or the child. * Children with generalized epilepsy or diffuse interictal spikes. * Children with severely impaired general status and vital functions. * Children with dermatosis of the face or scalp. * Children under the age of 6 years or adults over the age of 18 years.

Locations (1)

CHU Amiens

Amiens, France

Outcomes

Primary Outcomes

multimodal high-resolution EEG-NIRS

to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Time frame: Day 0

Secondary Outcomes

Functional MRI

to analyse the temporal dynamics of haemodynamic changes surrounding epileptic spikes.

Time frame: Day 0

Data from ClinicalTrials.gov

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