Brain Function in Children With Congenital Heart Disease (CHD)

Bea Latal50 enrolled

Overview

The purpose of the study is to determine whether the neurodevelopmental outcome and in particular executive functions in 9 to 14 year old school children with congenital heart disease who underwent cardiopulmonary bypass surgery during their first three months of life is impaired in comparison to healthy children at same age. Executive functions are higher order cognitive functions and critical for school success.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Congenital Heart Disease

Eligibility

Sex: ALLMin age: 9 YearsMax age: 14 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Congenital heart disease, * Cardiopulmonary bypass surgery during first three months of life, * No genetic syndrome, * Gestational age \> 37 weeks of gestation. Exclusion Criteria: * Heart surgery without cardiopulmonary bypass, * Heart surgery not within first three months of life, * Born \<37 weeks of gestation, * Any genetic syndrome detected.

Outcomes

Primary Outcomes

Executive Functions, assessed with D-KEFS

Time frame: 2 years

Secondary Outcomes

slow wave activity on EEG

Time frame: 2 years

MRI volumetry

Time frame: 2 years

Data from ClinicalTrials.gov

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