Post-operative atrial fibrillation (POAF) is a major and frequent complication occurring after cardiac surgery, contributing to prolonged intensive care and hospital stays and is associated with several cardiovascular complications. The exact mechanisms and signaling pathways involved in the development of POAF seem to be multifactorial and remain to date incompletely understood. β-blockers and amiodarone are the first line preventive drugs but are partially effective and near 30% of POAF resist to these strategies. In this context, there is some evidence indicating that renin-angiotensin-aldosterone system and Galectin-3 (Gal-3) share signaling pathways in the development of cardiac fibrosis and therefore could be very useful predictive biomarkers of POAF and potentially interesting therapeutic target to prevent POAF occurrence. The investigators hypothesis is that preoperative plasma aldosterone levels and galectin-3 (Gal-3) expression (in plasma, right atrial appendage or epicardial fat) could be predictive of POAF in patients undergoing elective CABG surgery with preserved LVEF.
Study Type
OBSERVATIONAL
Enrollment
500
Joachim ALEXANDRE
Caen, Basse Normandie, France
RECRUITINGOccurrence of atrial fibrillation in post-operative period of cardiac surgery (CABG +/- aortic valve replacement)
Time frame: 1 month
Find a correlation between the local secretion of aldosterone by adipocytes epicardial and the occurrence of AF during the 6 months after surgery in patients undergoing cold bypass coronary artery.
Time frame: 6 months
Find a correlation between aldosterone levels secreted in epicardial adipocytes and plasma aldosterone levels.
Time frame: 1 month
Find a correlation between preoperative plamastic aldosterone levels and occurence of postoperative atrial fibrillation
Time frame: 1 month
Detect aldosterone synthase aldosterone or angiotensin II (measured by quantitative and qualitative assays Western Blot, mRNA or RT-PCR) in the epicardial fat removed during surgery in patients undergoing a CABG.
Time frame: 1 month
Find a correlation between preoperative plamastic galectin-3 levels and occurrence of postoperative atrial fibrillation
Time frame: 1 month
Find a correlation between preoperative plamastic ngal levels and occurrence of postoperative atrial fibrillation
Time frame: 1 month
Find a correlation between preoperative mitochondrial function and occurrence of postoperative atrial fibrillation
Time frame: 1 month
Find a correlation between preoperative left atrial strain and occurrence of postoperative atrial fibrillation
Time frame: 1 month
Find a correlation between acute renal failure and occurrence of postoperative atrial fibrillation
Time frame: 1 month
Find a correlation between occurrence of postoperative atrial fibrillation and all cause cardiovascular morbimortality
Time frame: 2 years
Find a correlation between occurrence of postoperative atrial fibrillation and length of hospitalisation
Time frame: 1 month
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