Safety and Exploratory Efficacy Study of UCMSCs in Patients With Fracture and Bone Nonunion

Inclusion Criteria: * Every patient with non union in the site of bone fracture and nonunion. * Age more than 18 and less than 60 years old. * Nonunion or delayed union. Exclusion Criteria: * Diagnosis of cancer. * Pregnancy or breastfeeding. * Patient positive by serology or PCR for HIV, hepatitis B or C infection the patient with Accompanied fracture such as hip fracture that could not weight bearing. * Any medical or psychiatric condition that in the researcher´s opinion could affect the patient´s ability to complete the trial or hamper the participation in the trial. * Patients do not sign the consent forms