A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD

Inclusion criteria: Part 1, Part 2, Part 4 (Healthy subjects): * Male subjects aged 18-55 years; * Non smokers * Lung function above 80% of predicted normal value * Healthy subjects based on medical evaluation including medical history, physical examination, laboratory tests and cardiac testing * ability to produce an adequate induced sputum sample (study part 4 only) Part 3 (COPD patients): * Males and females aged 40-75 years * Current or past smokers * stable patients with a post-bronchodilator FEV1 between 40 and 80% of predicted normal value and FEV1/FVC ratio \<0.7 * Ability to produce a spontaneous and an adequate induced sputum sample Exclusion Criteria: Parts 1,2, 4 (Healthy subjects): * Any clinically relevant abnormalities and/or uncontrolled diseases * Abnormal laboratory values * Recent respiratory tract infection * Hypersensitivity to the drug or excipients * Positive serology results * Positive cotinine, alcohol, drug of abuse tests Part 3 (COPD patients): * Females of childbearing potential * History of asthma * Unstable concomitant diseases * Abnormal relevant Holter ECG parameters * Recent acute exacerbations of COPD or respiratory tract infection * Hypersensitivity to the drug or excipients * Positive serology results