The Drug -Drug Interaction of SP2086 and Glyburide

Inclusion Criteria: * Healthy volunteers with a body mass index(BMI) between 19 and 24 Kg/m2 * Had signed the informed consent himself or herself. Exclusion Criteria: * Have the abnormal lab or other examination results and the change have clinical significance. * Known allergy to SP2086 or Glyburide or any of the excipients of the formulation of SP2086 or Glyburide. * History of using the sulfa or sulfonylureas or DPP-IVor GLP-1 drugs or other similar structure drugs. * History of severe unconsciousness hypoglycemia * History of any surgery prior to screening in 6 months. * History of blood donation≥400 mL prior to screening in 3 months or participate in blood donation,or by blood transfusion in one month. * History of participate any drug or medical device prior to screening in 3 months. * Within a month before the screening using any prescription drugs, over-the-counter drugs, Chinese herbal medicine (especially oral antidiabetics drugs) or food supplements( vitamins). * 2 days before the randomization ,the patients can not ban alcohol, tobacco, or reference food or drink containing caffeine or xanthine , or vigorous exercise, or there are other factors that can affect drug absorption, distribution, metabolism and excretion. * The hepatitis B surface antigen, hepatitis c antibody, HIV antibody and syphilis antibody was positive. * Pregnancy or lactation women, or a fertility male or female is not willing to contraception during test. * Researchers considered that there was any situation that may cause the participants can't finish this study or bring any obvious risk to subjects.