Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Universitat Pompeu Fabra32 enrolled

Overview

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Cannabis

Interventions

Visuo-motor rotationBEHAVIORAL

Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.

Explicit strategyBEHAVIORAL

Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria. * Patients screen positive to cannabis in the urine analysis performed a week prior to assessment. * Right-handed patients. * Patients provide a signed consent. Exclusion Criteria: * Patients with another current substance use disorder (with the exception of tobacco). * Patients with a visual impairment that has not been corrected. * Patients with a cognitive impairment such as mental retardation. * Patients with psychotic disorders.

Outcomes

Primary Outcomes

Directional error of hand trajectories towards a target

Time frame: 1 day (a single session)

Secondary Outcomes

Reaction times

Time frame: 1 day (a single session)

Intrinsic Motivational Inventory

Time frame: 1 day (a single session)

Data from ClinicalTrials.gov

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