Pattern Scanning Laser Pan-retinal Photocoagulation in Proliferative Diabetic Retinopathy

United Christian Hospital17 enrolled

Overview

A randomized study to assess the safety and efficacy of single-session pan-retinal photocoagulation (PRP) using Pattern Scan Laser (PASCAL) in proliferative diabetic retinopathy (PDR) - 1,700 shots vs 2,500 shots

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Diabetic Retinopathy Lasers Treatment Outcome

Interventions

Pan-retinal photocoagulation using pattern scanning laserDEVICE

Patients receive the designated number of laser shots of pan-retinal photocoagulation with pattern scanning laser in a single session

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All treatment-naïve patients with proliferative diabetic retinopathy (PDR) who attended our ophthalmic clinic from 1st December 2012 to 30th November Exclusion Criteria: * significant media opacity affecting laser uptake (e.g. corneal opacity, mature cataract, dense vitreous haemorrhage) * any pre-existing ocular disorders resulting in visual impairment (e.g. retinal degenerations, maculopathies, primary glaucoma and other optic neuropathies) * those who received previous retinal laser treatment, intravitreal injections or intraocular surgeries * clinically significant macular oedema on clinical examination.

Outcomes

Primary Outcomes

Regression of neovascularization

Fluorescein angiogram assessment by independent observer

Time frame: 3 months

Secondary Outcomes

Activity of neovascularization

Descriptive analysis of fundus fluorescein angiogram by independent observer into 4 categories: no leakage, reduced leakage, same leakage, increased leakage

Time frame: 3 months

Best corrected visual acuity

Time frame: 1 week, 1 month, 3 months, 6 months

Complications

choroidal detachment, exudative retinal detachment, retinal breaks

Time frame: 1 week, 1 month, 3 months, 6 months

Central foveal thickness

Measured by spectral domain optical coherence tomography (Heidelberg Spectralis)

Time frame: 1 week

Retreatment rate

Patients requiring retreatment with pan-retinal photocoagulation

Time frame: 6 months

Data from ClinicalTrials.gov

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