FMT for MDRO Colonization in Solid Organ Transplant

Inclusion Criteria * Age ≥18 years old * Solid organ transplant recipients: liver, intestinal, multivisceral transplants, heart, lung, pancreas or kidney transplant recipients * Transplant recipient at least \>30 days post solid organ-transplant * Transplant recipient must be available locally for follow up to 6-months post FMT transplant * Inpatient status at time of FMT * History of at least one or more treated infections in the last 90 days (bacteremia, UTI, pneumonia or abdominal collection with a positive culture with MDRO) due to an MDRO and the MDRO is likely of enteric origin (carbapenem resistant enterobacteriaceae (CRE), vancomycin resistant enterococci (VRE) or carbapenem resistant Pseudomonas (CRP). * Be without active infection for \>15 days: bacteremia, UTI, pneumonia or abdominal collection. * Be without a positive culture (except for stool) with MDRO (carbapenem resistant enterobacteriaceae (CRE), vancomycin resistant enterococci (VRE) or carbapenem resistant Pseudomonas (CRP) * Patients are not receiving antimicrobials (therapeutic or suppressive) within 48 hours of FMT * Solid organ prophylactic antimicrobials as per protocol will be held 24 hours before and 14 days post FMT e.g. trimethoprim/sulfamethoxazole 3x/week or dapsone 100 mg PO daily or weekly for PJP prophylaxis * Ganciclovir or valgancyclovir for CMV prophylaxis if required as per protocol can be continued. * Patients have a positive surveillance rectal culture for evidence of colonization. Exclusion Criteria * Inability to provide informed consent * Physician-documented, severe allergy to nuts or other food allergens * Patients with allergies to ingredients Generally Recognized As Safe " glycerol, sodium chloride * Study participants hospitalized in the intensive care unit * CMV IgG, EBV IgG and PCR negative at the time of consent * Biological MELD score \> 28 as defined by transplant surgeon * Pregnancy or inability/unwillingness to use contraceptives. * Autoimmune hepatitis * Patients that received a new solid organ transplant within the last 30 days at the time of enrollment * Patients on antibiotics treating an active infection or less than 2 weeks at the time of enrollment * Any circulatory failure on vasopressors * Respiratory failure (on mechanical ventilation) at the time of enrollment * Renal failure (GFR \<30 or dialysis) at the time of enrollment * Any active Clostridium difficile infection regardless of severity * Post-allogeneic hematopoietic stem cell transplant recipients * ANC \<1000/mm3 * HIV+ controlled or not well controlled on antiretroviral therapy * At increased risk for peritonitis: presence of intra-abdominal devices, peritoneal dialysis. * Previous FMT * Patients undergoing treatment for liver or any other organ transplant rejection * Patients with graft vs. host disease * Patients with any active infection (bacteremia, pneumonia, urinary tract infection or abscess) * Life expectancy \<1-year post transplant * Any clinical significant bleeding from a lower GI source (as defined as requiring blood transfusion, endoscopy or surgical or radiologic intervention) in the last 30 days. * Any condition that the physician investigators deems unsafe, feel the risks of outweigh potential benefit, including other conditions or medications that the investigator determines puts the subject at greater risk from FMT