Evaluate the therapeutic effects health benefits, and immunological effect of Nigella sativa in children with beta thalassemia major.
Study will be carried on children patients with β- thalassemia major attending The Hematology Unit of Pediatric Department at Tanta University Hospital. patients are divided into 2 groups: patients in the control group, patients in the treatment group that will receive nigella sativa powder for 3 consecutive months. Then Evaluate the therapeutic effects health benefits, and immunological effect of Nigella sativa in children with beta thalassemia major. Evaluate the extent of clinical improvement, reductions in serum iron and ferritin, antioxidant status, treatment of the causes of hemolysis and other therapeutic benefits of Nigella sativa in those patient.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
nigella sativa powder (2 gm/day) for 3 consecutive months.
Faculty of Medicine- Tanta University
Tanta, Gharbia Governorate, Egypt
RECRUITINGmalondialdehyde
nmol serum level of malondialdehyde (nmol per liter)
Time frame: 3 months
cluster of differentation4 and 8(CD4 and CD8)
CD4 and CD8 cell per cmm
Time frame: 3 months
total antioxidant
total antioxidant(mmol per liter)
Time frame: 3 months
Serum iron
microgram per dl
Time frame: 3 months
total iron binding capacity
microgram per dl
Time frame: 3 months
serum ferritin
ng per ml
Time frame: 3 months
complete blood count
complete blood count
Time frame: 3 months
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