Transcranial magnetic stimulation for post-stroke upper-body motor deficits.
This study uses transcranial magnetic stimulation (magnetic pulses delivered through a specially designed cap worn on the head aimed at specific motor areas of the brain (brain areas responsible for the body's physical movements) to test whether upper-body motor function can be improved. This is a double-blind study where half of participants will receive active transcranial stimulation and the other half of the participants will receive no transcranial magnetic stimulation; all participants will wear the cap. Participants and some members of the research team will not know who received active magnetic brain stimulation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
38
Cap worn on the scalp will deliver active Repetitive Transcranial Magnetic Stimulation to specific parts of the brain
Cap worn on the scalp will no delivery of the Repetitive Transcranial Magnetic Stimulation to any part of the, referred to as a sham or inactive study treatment.
Houston Methodist Hospital
Houston, Texas, United States
Changes in Brain Activation
Change in number of active voxels in the cortical areas surrounding the lesion on functional MRI
Time frame: One business day before treatment begins, one business day after treatment ends, up to 5 weeks
Fugl-Meyer Motor Arm Score
Change in arm motor function Total score range is 0-66 with the higher number representing a better outcome
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks
ARAT (Action Research Arm Test)
Change in arm and hand motor function Total score range is 0-57 with the higher number representing a better outcome
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks
Hand Dynamometer
Change in grip strength The higher the number represents better outcome
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks
Pinch Dynamometer Score
Change in pinch strength. The higher the number, the better the outcome.
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks
TUG (Timed Up and Go Test)
Change in gait velocity on Timed Up and Go Test. The lower the time recorded, the better the outcome.
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks
National Institutes of Health Stroke Scale (NIHSS)
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Change in National Institutes of Health Stroke Scale (NIHSS) Total score range is 0-42 with the lower number representing a better outcome
Time frame: One business day before treatment begins, one business day after treatment ends up to 5 weeks