Thoracic Paravertebral Block : Effect on Acute Pain and Chronic Pain of Hepatectomy With Right J-shape Subcostal Incision

Cui Xulei76 enrolled

Overview

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Hepatectomy Analgesia Nerve Block

Interventions

single-injection TPVB + continuous TPVBPROCEDURE

Inject local anesthetics in the T8 paravertebral space followed with catheter insertion and continuous local infusion.

Philip CX50 Ultrasound ScannerDEVICE

The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scanning

PAJUNK Contiplex S CatheterDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo hepatectomy with J-shape subcostal incision * Informed consent Exclusion Criteria: * A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Locations (1)

Xulei CUI

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

cumulative morphine consumption

Time frame: within 48 postoperative hours

Secondary Outcomes

The pain scores determined by the numeric rating scale (NRS, 0-10)

Time frame: At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery

nausea and vomiting score

Time frame: At 0, 2,4, 8, 12, 24 and 48hours after the surgery

pruritus score

Time frame: At 0, 2,4, 8, 12, 24 and 48hours after the surgery

ambulation time

Time frame: within the 7 days after surgery

time of recovery of bowl movement

Time frame: within the 7 days after surgery

Postoperative hospital length of stay

Time frame: Up to 4 weeks

patient satisfaction with anesthesia

use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia

Time frame: 48 hours after surgery

data collection of chronic pain

Patients undergo a telephone interview with a questionnaire at 3, 6 and 12 months after surgery, the incidence and severity of chronic pain is recorded.

Time frame: at 3,6,12 months after surgery

Data from ClinicalTrials.gov

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