Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation

Chang Gung University30 enrolled

Overview

Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. The objective of this study was to evaluate inhaled bronchodilator and mucolytic agents delivered through a ventilator system.

Aerosolized medication is used widely to patients with respiratory illness and admitted in the intensive care unit, and includes bronchodilators, steroids, mucolytics, and antibiotics. Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. Only few clinical trials on aerosol delivery deposition were published in the last decades. In addition, inhaled bronchodilators, mucolytics, antibiotics, and steroids are often administered to ventilated patients in the intensive care units in Taiwan, but they are never studied. Therefore, the aim of this study was to evaluate inhaled bronchodilator and mucolytics (acetylcystine) delivered by a jet nebulizer through a ventilator system to intubated patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

SalbutamolDRUG

Salbutamol (albuterol ) was delivered by a jet nebulizer with a 50 pis oxygen flow at 6 L/min.

AcetylcysteineDRUG

Acetylcystine was delivered by a jet nebulizer with a 50 pis oxygen flow at 6 L/min.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mechanical ventilated patients with an endotracheal tube intubated * Receiving aerosol therapy with salbutamol or acetylcystine * On relatively stable medical condition Exclusion Criteria: * Pregnant * Unstable hemodynamic status (e.g. blood pressure \<100/60 mmHg, under Intra-aortic balloon pump) * Infected with airborne pathogens (e.g. tuberculosis or Influenza virus) * Poor oxygenation (fraction of inspiratory oxygen \>0.8, under high frequency oscillatory ventilation, or extracorporeal membrane oxygenation)

Locations (1)

Chiayi Chang Gung Memorial Hospital

Chiayi City, Taiwan

Outcomes

Primary Outcomes

Inhaled drug dose

Drug depositions in inspiratory filters were analyzed by a spectrophotometer.

Time frame: Inhaled drug dose was collected Immediately after each nebulization, expected average of 20 minutes

Secondary Outcomes

exhaled drug dose

Drug depositions in expiatory filters were analyzed by a spectrophotometer.

Time frame: Exhaled drug dose was collected Immediately after each nebulization, expected average of 20 minutes

Data from ClinicalTrials.gov

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