Small Intestinal Bacterial Overgrowth Obese

N/ACompletedNCT02819037

Lille Catholic University51 enrolled

Overview

The objective of this research is to determine the incidence of microbial overgrowth of the small intestine before and after a gastric bypass. For this purpose, the study is based on the analysis of the expired hydrogen H2 with gas chromatography before surgery and at 1, 3, 6, 12, 18 and 24 months.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Gastric Bypass Blind Loop Syndrome Bacterial Overgrowth Syndrome Chromatography, Gas

Interventions

gas chromatographyPROCEDURE

Stool analysis for detection of malabsorptionPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Severe obesity (BMI\>35kg/m² with at least one comorbidity or BMI\>40kg/m² without comorbidity) and after medical care for at least 6 months * Patient who will follow bariatric surgery by bypass gastric * Social insurance affiliation * Signature of the informed consent Exclusion Criteria: * Contraindication criteria for bariatric surgery (cognitive or mental severe disorders, severe and non-stabilized eating disorders, etc.) * Chronic inflammatory bowel disease (Crohn's disease, hemorrhagic rectocolitis) * Previous intestinal surgery * Antibiotic periodicity treatment of less than 3 months * Other diseases responsible for bacterial overgrowth * Pregnancy or breastfeeding

Locations (2)

Centre Hospitalier d'Arras

Arras, France

Centre Hospitalier de Douai

Douai, France

Outcomes

Primary Outcomes

Changes in expired hydrogen H2 concentration

Measured by gas chromatography

Time frame: change at baseline et up to 24 months

Secondary Outcomes

Changes in digestive symptoms

Time frame: change at baseline et up to 24 months

Changes in intestinal transit

Characterisation of intestinal transit by measuring stool frequency

Time frame: change at baseline et up to 24 months

Changes in malabsorption

Detection of lipids, vitamins (A, B1, B9, B12, D, E), zinc, magnesium, phosphorus, serum iron and protein balance (albumin, prealbumin, CRP) in order to diagnosis the presence of malabsorption

Time frame: change at baseline et up to 24 months

Data from ClinicalTrials.gov

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