Study Assessing Evaluation of the Interest of Serum S100B Protein Determination in the Management of Pediatric Mild Traumatic Brain Injury

Inclusion Criteria: * Age ≤ 16 years Therapeutic management within 3 hours after TBI GCS score of 15 classically requiring hospitalization and/or CCT-scan as per SFP recommendations (Lorton et al., 2014). These criteria are: * For children aged under 2 years (CCT-scan or hospitalization recommended according to physician's evaluation): * Parietal or occipital scalp hematoma, * Loss of consciousness for more than 5 seconds, * Trauma due to serious accident (road accident with passenger ejected from vehicle or death of another person or rollover; pedestrian hit by a moving vehicle; cyclist not wearing a helmet; fall from a height greater than 0.9 meter), * Abnormal behavior in the opinion of parents. * For children 2 years and older (CCT-scan or hospitalization recommended according to physician's evaluation): * Loss of consciousness at time of accident, * Vomiting, * Trauma due to serious accident (road accident with passenger ejected from vehicle or death of another person or rollover; pedestrian hit by a moving vehicle; cyclist not wearing a helmet; fall from a height greater than 1.5 meter), * Severe headache. Exclusion Criteria: * Patient already enrolled in another therapeutic trial with drug administration Down syndrome Melanoma Refusal of child Refusal of parents or legal guardian Trauma more than 3 hours earlier GCS score of 13 or 14, or signs of skull fracture or lesions of the skull base (CCT-scan recommended) Children with TBI not requiring hospitalization and/or CCT-scan as per SFP recommendations (Lorton et al., 2014). This group is defined by the absence of the following criteria: * GCS score different from 15, * Age \< 3 months, * Seriousness of accident: * road accident with passenger ejected from vehicle or death of another person or rollover, * pedestrian hit by a moving vehicle, * cyclist not wearing a helmet. * Fall: * of more than 0.9 m before age 2 years, * of more than 1.5 m after age 2 years. * Loss of consciousness for 5 seconds or more, * Inconsolable crying, * Agitation, drowsiness, feeling "slowed down", obnubilation, * Vomiting or headache, * Facial or cranial hematoma, * Otorrhea, rhinorrhea, * Child under 2 years old, * Loss of consciousness for less than 5 seconds, * Unusual behaviour, * Concern of family members