The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

N/AUnknownNCT02820090

Beijing Chao Yang Hospital300 enrolled

Overview

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Systemic Inflammatory Response Syndrome Ventilator Weaning

Eligibility

Sex: ALLMin age: 14 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure * mechanical ventilation time over than 48 hours * Glasgow score greater more than or equal to 13 points Exclusion Criteria: * Aged less than 14 years or more than 80 years old * patients with neuromuscular disease * pure heart failure pulmonary edema patients * patients with tracheotomy

Outcomes

Primary Outcomes

The relationship between mechanical ventilation of ventilator and inflammatory response

Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related.

Time frame: January 2014 to December 2016

Secondary Outcomes

The relationship between diaphragm movement function and weaning from mechanical ventilation

To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation.

Time frame: January 2016 to December 2017

the output of CO2

Time frame: January 2016 to December 2017