The purpose of this study is to assess the degree of agreement of the measurement of differential renal function in living donors by CT (computed tomography) and SPECT (single photon emission computed tomography).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
51
Low dose 4D (perfusion) renal acquisition after injection of iodinated contrast medium (ICM) (13 passes every 3 seconds, 3 passes every 10 seconds); estimated additional DLP 400 mGy.cm No additional contrast medium
CHRU Nancy
Nancy, France
degree of agreement
Differential renal function (DRF) measured by each technique (CT and SPECT) Regions of interest will be drawn on each kidney and the aorta to obtain time-intensity curves and derive the Patlak plot; the Patlak model will then be used to determine the slope of each kidney and thus to calculate the differential renal function (percentage of each kidney in the total renal function). Degree of agreement will be assessed by calculating the intra-class correlation coefficient and its 95% confidence interval, and the Bland-Altman plot.
Time frame: through study completion (2 years)
Intra- and inter-observer reproducibility of CT DRF measurement
Time frame: through study completion (2 years)
Radiation dose exposure for each technique
Additional radiation dose exposure (CTDIvol and DLP) will be recorded and follow-up
Time frame: 1 day
Agreement between post-processing methods for CT
Comparison between Patlak-Ruthland method, its modified version and the area under the curve method
Time frame: through study completion (2 years)
Automatic post-processing for Patlak-Ruthland method
Time frame: through study completion (2 years)
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