Rationale. Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men. Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
16
40 hours of continuous wakefullness
ACh induced Vasodilation during TSD
Cutaneous vasodilation (in % Baseline) induced by local application of Acethylcholine
Time frame: Up to 09:00 during sleep deprivation (i.e. after 26 hours of wakefulness)
Insuline Vasodilation
Cutaneous vasodilation (in % Baseline) induced by local application of insulin
Time frame: Up to 09:00 during the sleep deprivation day and the recovery day
Heat vasodilation
Cutaneous vasodilation (in % Baseline) induced by local application of heat (42°C)
Time frame: Up to 9:00 during the sleep deprivation day and during the recovery day
Inflammation
Plasma levels of inflammatory marquers (TNF-alpha, IL1beta...)
Time frame: Up to 7:00 during the sleep deprivation day and during the recovery day.
blood pressure
Mean, systolic and diastolic blood pressure
Time frame: Every 3 hours during the 40 hours of wakefullness (i.e. total sleep deprivation)
PWV
Pulse wave velovity evaluated by echography
Time frame: Up to 09:00 during the sleep deprivation day
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