Eccentric Motor Control After SCI

Ohio State University49 enrolled

Overview

This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at slow to moderate speeds - targeted to rehabilitation eccentric function of the hip and knee.

Lower extremity eccentric motor control is is critically important for locomotor function but is impaired after spinal cord injury (SCI). Even after treadmill training, preliminary evidence indicates that eccentric deficits persist among individuals with SCI. This proposal aims to characterize eccentric motor control of the muscles about the hip and knee during locomotion and evaluate the efficacy of downhill gait training at slow speeds as an intervention to improve eccentric function of the hip joint and knee joint during walking.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Spinal Cord Injury

Interventions

Untrained and Trained SCI Hip or KneeBEHAVIORAL

Individuals with SCI will perform downhill walking training 3 times a week for 12 wks with a 4 wk follow-up period. This intervention will be delivered by trained therapists. In order to focus on rehabilitation of hip control or knee control, members of this group will be trained at slow to moderate gait speeds,

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Individuals with SCI: Inclusion Criteria: * medically approved * discharged from outpatient rehabilitation for 6 months * incomplete SCI based on ASIA impairment score (AIS C or D) at neurologic level C1-T10 * ability to take some steps overground and on the treadmill * 18-90 years old. * ability to speak English. Note: the quality of life measures have not been validated yet in non-English speaking populations. Exclusion Criteria: * evidence of lower motor neuron injury in the legs * use of botox in the past 3 months * pre-existing or confounding neurologic conditions (i.e. brain injury, stroke, HIV) * acute deep vein thrombosis * skin wounds in regions where harness or hands provide support * pregnancy. Note: Persons who are pregnant will not be enrolled as exercise tolerance is unknown in these women with SCI. * cognitive conditions that preclude providing informed consent * ventilator-dependence as study results will be confounded by mobility limitations imposed by equipment * persistent orthostatic hypotension (drop of BP \>30mmHg in treadmill and harness equipment) * hospitalization for myocardial infarction, cardiac surgery or congestive heart failure exacerbation within 3 months of enrollment in study * participation in any other concurrent exercise programs. Note: Use of anti-spasticity and other medications (dose, frequency) will be monitored throughout training and used as a confounding variable in the analyses.

Locations (1)

The Ohio State University

Columbus, Ohio, United States

Outcomes

Primary Outcomes

Change from baseline in time to complete 6 minutes of level walking (i.e., the 6 minute walk test)

Time frame: baseline, 12 weeks

Secondary Outcomes

Change from baseline in time to complete 10 meters of level walking (i.e., the 10 meter walk test)

Time frame: baseline, 12 weeks

Change from baseline in peak magnitude of frontal hip loading response as measured by the peak magnitude of frontal hip power absorption during the weight acceptance phase of walking

Time frame: baseline, 12 weeks

Data from ClinicalTrials.gov

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