All eligible subjects were randomly assigned to group A and group B sequences, each sequence has 12 subjects. The SP2086 were given limosis,then after the meal,then limosis.In the study ,the investigators collected the blood samples,urine samples and fecal samples to analyze.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
The First Hospital of Jilin University
Changchun, Jilin, China
RECRUITINGThe maximum plasma concentration (Cmax) of SP2086
Cmax (a measure of the body's exposure to SP2086) will be compared before and after administration of a single dose of SP2086
Time frame: up to Day 12
The maximum plasma concentration (Cmax) of SP2086 acid
Cmax (a measure of the body's exposure to SP2086 acid) will be compared before and after administration of a single dose of SP2086.
Time frame: up to Day 12
The area under the plasma concentration-time curve (AUC) of SP2086
AUC (a measure of the body's exposure to SP2086) will be compared before and after administration of a single dose of SP2086.
Time frame: up to Day 12
The area under the plasma concentration-time curve (AUC) of SP2086 acid
AUC (a measure of the body's exposure to SP2086 acid) will be compared before and after administration of a single dose of SP2086.
Time frame: up to Day 12
Cumulative percentage drainage of SP2086 in urine
Time frame: up to Day 12
Cumulative percentage drainage of SP2086 in fecal
Time frame: up to Day 12
The number of volunteers with adverse events as a measure of safety and tolerability
Time frame: up to Day 12
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