Cohort of STEMI Patients

Hospices Civils de Lyon1,204 enrolled

Overview

Ischemic heart disease is the leading cause of mortality in industrialized countries. ST elevated acute myocardial infarction is one of its most frequent and deadly manifestation. In the last 20 years, STEMI mortality has been reduced by 50% with the advent of timely reperfusion (primary percutaneous intervention) and significant progression in pharmacologic intervention. However, death and heart failure incidence after STEMI remain elevated: up to 20% at one year. Also, therapeutic management following international guidelines is standardized toward a "one-size fits all" therapeutic management. In order to continue improving myocardial infarction outcomes, there is a need to better understand and individualize therapeutic targets such myocardial reperfusion injury, post reperfusion inflammation, adverse left ventricular (LV) remodeling …. This knowledge will allow us to propose new therapeutic strategies and in the long run strive towards personalized medicine. The aim objective of this cohort of STEMI patients is to identify new biological markers of injury and prognosis.

Study Type

OBSERVATIONAL

Enrollment

1,204

Conditions

Myocardial Infarction

Interventions

STEMI PATIENT Cohort

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 18 years * Diagnosis of STEMI defined by ST segment elevation ≥ 0.2 mV in 2 contiguous leads on a 12-lead ECG. * Primary PCI within 12 hours of symptoms onset. Exclusion Criteria: * Diagnosis of STEMI not confirmed by angiography * Refusal to participate in the study or to sign the consent * Inability to give information to the subject about the study * Lack of medical social coverage * Deprivation of civil rights

Outcomes

Primary Outcomes

Change in Troponin

Dosage of Troponin at hospital admission and 4 hours after Percutaneous coronary intervention (PCI)

Time frame: Day 0

Change in Creatine Kinase

Dosage of Creatine Kinase at hospital admission and 4 hours after PCI

Time frame: Day 0

Secondary Outcomes

New York Heart Association (NYHA) Class

Time frame: at admission (Day 0)

Left ventricular ejection fraction (LVEF)

LVEF measured by echocardiography

Time frame: 24 hours after PCI (Day 1)