The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
The purpose of this study is to determine the weight-independent effects of gastric bypass surgery and sleeve gastrectomy surgery on islet cell response after meal ingestion as mediated by hormonal and neural components of the gut. It will also address the differences between the two procedures. Such information will be critical for the development of novel approaches for treatment of diabetes as well as improvement of glycemic effects of gastric bypass and sleeve gastrectomy in patients with partial diabetes remission or relapse after complete remission.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
200
A physiological study to evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
A physiological study to evaluate the effect of neural activation on insulin secretion and glucose metabolism.
Texas Diabetes Institute - University Health System
San Antonio, Texas, United States
RECRUITINGSouth Texas Veterans Health Care System
San Antonio, Texas, United States
RECRUITINGInsulin levels measured after nutrient ingestion
Time frame: Each study in the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.
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