Effects of Laugh Therapy Associated to Cardiopulmonary Rehab

Inclusion Criteria: * ischemic heart disease diagnosis established by cardiac catheterization, with 50% lesion in at least one epicardial vessel (if the patient has had an acute coronary syndrome or have been revascularized, the event time is expected to exceed 6 months). * Both sexes * With availability to come to HCPA twice a week * In conditions of entering into a cardiac rehabilitation program with exercise. Exclusion Criteria: * Involvement in another clinical trial. * Presence of autoimmune disease * Use of oral anticoagulant * Valvulopathy with mechanical or biological cardiac prosthesis * Presence pacemaker or implantable cardioverter * Left bundle branch block in 12-lead ECG * severe lung disease * Major Depression or Bipolar Disorder * Chronic Atrial Fibrillation * Left ventricular dysfunction (ejection fraction \<45%) * Active infection or cancer (other than basal cell carcinoma) * Chronic Renal Failure * Illiteracy * Inability to understand the consent form