The goal of this project is to investigate and improve executive control function in two distinct pain conditions, namely neuropathic pain and fibromyalgia (FM). It is hypothesized that there is a significant difference in the executive control function of patients with neuropathic pain and FM pain. It is also hypothesized that all participants with poor executive control functioning will report significant improvements in pain intensity, functioning and cognitive complaints following cognitive training. The study tests and influence the working memory concepts of inhibition, updating and flexibility through an experimental, cross-over treatment design. To perform the experiment, we will recruit 160 participants (80 with neuropathic pain and 80 with FM) from the Departments of pain management and research at St Olav's University Hospital and Oslo University Hospital (OUS). The proposed design will be able to determine whether or not executive control, processing speed and memory function differs in two distinct populations of pain patients. Moreover, whether impairments are amended by computerized training.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
82
Training mental flexibility
Used as control for time spent on computer
Oslo University Hospital
Oslo, Norway
Objective neuropsychological tests
CANTAB test battery
Time frame: 36 weeks
Pain intensity
VAS scale
Time frame: 36 weeks
Stress regulation
Hair cortisol
Time frame: 36 weeks
Symptoms of depression
Hopkins symptom checklist
Time frame: 36 weeks
Sleep duration, quality and awakening
Actigraphy
Time frame: 36 weeks
Quality of life
EQ-5D
Time frame: 36 weeks
Medication use
Registered analgetic usage
Time frame: 36 weeks
Self-reported memory and concentration impairments
Everyday Memory Questionnaire
Time frame: 36 weeks
Self-reported cognitive intrusion
Questionnaire
Time frame: 36 weeks
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