Sugar alcohols such as xylitol and erythritol are increasingly popular as sugar substitutes in the food industry and are also recommended to diabetic patients. Both substances are already in use in the food industry and are freely available. Since the 1970s, beneficial effects on oral health could be demonstrated as oral bacteria were influenced positively. Animal studies showed an increase in gut Clostridium perfringens after xylitol intake; certainly a non-desirable effect. However, studies on effects of erythritol and xylitol on the human gut microbiota are lacking so far. In this trial, investigators aim to examine whether gut microbiota and glucose tolerance can be influenced by polyol intake in a non-diabetic but obese cohort.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
64
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital
Oslo, Norway
Endoscopic and Minimally Invasive Surgery Clinic of Stavropol State Medical University
Stavropol, Russia
St Claraspital
Basel, Switzerland
Glucose tolerance measured with oral glucose tolerance test
Time frame: change from baseline to 8 weeks after polyol intake
Human gut microbiota composition measured with metagenomic shotgun sequencing
Time frame: change from baseline to 8 weeks after polyol intake
Gut microbial-related metabolites in feces
Metabolomic analysis of the bacterial metabolites present in the feces by combining nuclear magnetic resonance (1H-NMR) and mass spectrometry
Time frame: change from baseline to 8 weeks after polyol intake
Gastrointestinal tolerance assessed by questionnaire
Gastrointestinal Symptoms Rating Scale (Svedlund et al)
Time frame: change from baseline to 8 weeks after polyol intake
Gut microbial-related metabolites in urine
Metabolomic analysis of the bacterial metabolites present in the urine by combining nuclear magnetic resonance (1H-NMR) and mass spectrometry
Time frame: change from baseline to 8 weeks after polyol intake
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