Strigolactones and Dysplastic Colonic Lesions or Cancer

Meir Medical Center150 enrolled

Overview

The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.

Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Colonic Neoplasms Colonic Polyps

Interventions

biopsy during colonoscopyPROCEDURE

sampling the lesion with forcept biopter

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with positive findings during colonoscopy Exclusion Criteria: * Patients below 18 years old * Patients who cannot sign a consent form

Outcomes

Primary Outcomes

percentage of cells with reduced viability after dose-dependent exposure

Time frame: 24 hours of exposure to strigolactone

percentage of cells in G2/M arrest after dose-dependent exposure

analysis of cell cycle

Time frame: 24 hours of exposure to strigolactone

Central Contacts

Ido Laish, MD

CONTACT

+ 972-9-7473261 ido.lish@clalit.org.il

Data from ClinicalTrials.gov

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