Efficacy Testing of Djulis-Buckwheat Drink on Cardiovascular Protection

Taipei Medical University Hospital

Overview

The purpose of the trial is to evaluate the effect of Djulis-Buckwheat drink on cardiovascular protection after ingesting for 8 weeks. In addition, the correlation between the supplement and the cardiovascular disease-related gene expression is evaluated. The results will be used for the application of functional products for cardiovascular protection. Ninety subjects (age 30\~65) with Prehypertension or Hypertension stage 1 will be included and randomly allocated into 3 groups: Placebo, Djulis-Buckwheat and Buckwheat. The subjects will take sample (100 ml/day) for 8 weeks. Blood pressure will be measured on week 0, 1, 2, 4, 6 and 8. The blood biochemical parameters and gene expression analysis will be examined on week 2, 4, 6, 8 and 10 (the follow up).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Conditions

Prehypertension Hypertension Stage 1

Interventions

PlaceboDIETARY_SUPPLEMENT

Ingest placebo drink 100ml/day for 8 weeks

Djulis-BuckwheatDIETARY_SUPPLEMENT

Ingest Djulis-Buckwheat drink 100ml/day for 8 weeks

BuckwheatDIETARY_SUPPLEMENT

Ingest Buckwheat drink 100ml/day for 8 weeks

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Systolic blood pressure 121-159 mmHg or Diastolic blood pressure 81-99 mmHg * Age: 30-65 Exclusion Criteria: * Have diagnosed and documented critical illness(NHI specification) * Had emergency record or admission note in the past three months * Not be pregnant or breast-feeding a child

Outcomes

Primary Outcomes

Change of blood pressure

Time frame: Baseline, 1, 2, 4, 6, and 8 weeks

Data from ClinicalTrials.gov

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