A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection

Inclusion Criteria: All subjects: * 18 to 65 years inclusive * Women of child-bearing potential must have a negative pregnancy test, cannot be breast feeding, and must be willing to use a highly effective method of contraception * Agrees not to donate blood during the duration of the study * Willing to comply with the study requirements and to provide written informed consent Additional inclusion criteria for patients with HBV infection: * Body mass index (BMI) ≥18.0 kg/m2 * Must be on a stable regimen of entecavir or tenofovir Exclusion Criteria: All subjects: * Any uncontrolled or serious disease, or any medical or surgical condition, that may either interfere with participation in the clinical study, and/or put the subject at significant risk * Subjects with a history of serious mental illness * Active infection with human immunodeficiency virus (HIV) infection, hepatitis A virus (HAV), or hepatitis C virus (HCV) infection and/or a history of delta virus hepatitis * Known hypersensitivity or contraindication to any medication or history of allergic reaction to an oligonucleotide or N-acetylgalactosamine (GalNAc) Additional exclusion criteria for healthy volunteers: * Evidence of liver disease