This study includes comatose survivors of out-of-hospital cardiac arrest treated with 24 hours or 48 hours of targeted temperature management. The overall aim is to evaluate the importance of plasma complement protein concentrations in patients resuscitated after out-of-hospital cardiac arrest and treated with 24 hours or 48 hours of targeted temperature management. The specific aim is to evaluate: * the concentration of plasma lectin pathway proteins the first, second and third day after cardiac arrest * the relation between concentration of plasma lectin pathway proteins and mortality * if prolonged targeted temperature management influences the concentration of plasma lectin pathway proteins This study is a sub-study to the trial entitled: "Time-differentiated targeted temperature management (TTH48) (ClinicalTrials.gov Identifier: NCT01689077)" The following Complement Lectin Pathway proteins will be measured: Mannan-Binding-Lectin, M-ficolin, H-ficolin, CL-L1, MASP-1, MASP-2, MASP-3, MAp19 and MAp44.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
82
Department of Biomedicine, Aarhus University
Aarhus, Denmark
Department of Anesthesiology and Intensive Care, Aarhus University Hospital
Aarhus, Denmark
Department of Clinical Biochemistry, Aarhus University Hospital
Aarhus, Denmark
MASP-2 concentration in plasma
Time frame: 48 hours
MASP-2 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
MASP-2 concentration in plasma
MASP-2 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
MASP-2 concentration in plasma
Time frame: 24 hours to 72 hours
MASP-1 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
MASP-1 concentration in plasma
Time frame: 24 hours to 72 hours
MASP-1 concentration in plasma
MASP-1 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
MASP-3 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
MASP-3 concentration in plasma
Time frame: 24 hours to 72 hours
MASP-3 concentration in plasma
MASP-3 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
Mannan-Binding-Lectin concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
Mannan-Binding-Lectin concentration in plasma
Time frame: 24 hours to 72 hours
Mannan-Binding-Lectin concentration in plasma
Mannan-Binding-Lectin concentration in plasma compared to 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
MAp44 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
Map44 concentration in plasma
Time frame: 24 hours to 72 hours
MAp44 concentration in plasma
MAp44 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
MAp19 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
MAp19 concentration in plasma
Time frame: 24 hours to 72 hours
MAp19 concentration in plasma
MAp19 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
H-ficolin concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
H-ficolin concentration in plasma
Time frame: 24 hours to 72 hours
H-ficolin concentration in plasma
H-ficolin concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
M-ficolin concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
M-ficolin concentration in plasma
Time frame: 24 hours to 72 hours
M-ficolin concentration in plasma
M-ficolin concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
CL-L1 concentration in plasma
Time frame: 24 hours, 48 hours and 72 hours
CL-L1 concentration in plasma
Time frame: 24 hours to 72 hours
CL-L1 concentration in plasma
CL-L1 concentration in plasma compared with 30-day mortality
Time frame: 24 hours, 48 hours, 72 hours
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