Penetrating keratoplasty (PKP) is an open-sky surgery that fundamentally has not changed for more than 100 years. Because conventional PKP is associated with the potential for the development of devastating complications such as expulsive suprachoroidal hemorrhage and endophthalmitis, we modified the technique to one that is a closed surgery under topical anesthesia with the anterior chamber maintained to achieve favorable results. Topical anesthesia is an attractive alternative to traditional injection local anesthesia since the potentially serious complications associated with retrobulbar and peribulbar anesthesia can be avoided. The closed PKP procedure with the stable anterior chamber essentially changes the open nature of conventional PKP. The advantages, i.e., decreased surgical risks, postoperative complications, and surgical difficulties, make PKP viable in most complicated cases.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
a closed corneal transplantation under topical anesthesia with the anterior chamber maintained
an open-sky corneal transplantation under retrobulbar anesthesia
Anti-Rejection Agents for both groups
Anti-Inflammatory Agents for both groups
Eye Hospital, Wenzhou Medical College
Wenzhou, Zhejiang, China
RECRUITINGbest corrected visual acuity
Time frame: preoperative
best corrected visual acuity
Time frame: 1 week after PKP
best corrected visual acuity
Time frame: 2 weeks after PKP
best corrected visual acuity
Time frame: 1 month after PKP
best corrected visual acuity
Time frame: 3 months after PKP
best corrected visual acuity
Time frame: 6 months after PKP
Endothelial cell density
Time frame: 1 week after PKP
Endothelial cell density
Time frame: 2 weeks after PKP
Endothelial cell density
Time frame: 1 month after PKP
Endothelial cell density
Time frame: 3 months after PKP
Endothelial cell density
Time frame: 6 months after PKP
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.