Evaluation of Novel Lung Function Parameters and Quantitative Computed Tomography (qCT) in Patients With Pulmonary Disease

Universitätsmedizin Mannheim100 enrolled

Overview

Current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Chronic Obstructive Pulmonary Disease Bronchial Asthma Interstitial Lung Disease

Interventions

multiple breath washout test (MBW)DEVICE

impulse oscillometry (IOS)DEVICE

body plethysmography (BP)DEVICE

quantitative computed tomography (qCT)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * known or suspected pulmonary lung disease * indication for computed tomography Exclusion Criteria: * pregnancy * inability to participate

Locations (1)

Universitätsmedizin Mannheim

Mannheim, Germany

RECRUITING

Outcomes

Primary Outcomes

correlation of lung clearance index (LCI) as determined by multiple breath washout with emphysema quantification as determined by qCT

Time frame: 2 weeks

correlation of airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry with emphysema quantification as determined by qCT

Time frame: 2 weeks

correlation of residual volume and airway resistance as determined by body plethysmography with and emphysema quantification as determined by qCT

Time frame: 2 weeks

Central Contacts

Frederik Trinkmann, Dr.

CONTACT

+496213833879 frederik.trinkmann@umm.de

Data from ClinicalTrials.gov

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