CAREFOR: Precision Medicine Driving Precision Nutrition for the Treatment of NeoAdjuvant Breast Cancer

Inclusion Criteria: * Pathologically proven invasive breast cancer * Planned neoadjuvant chemotherapy determined by the judgment of the medical oncologist * The patient must be female * Age ≥ 18 * Non-metastatic and non-inflammatory breast cancer * History/physical examination, including breast exam and documentation of weight and Karnofsky Performance Status of 80-100% for at least 60 days prior to study entry. * Women of childbearing potential must be non-pregnant and non-lactating and willing to use medically acceptable form of contraception during chemotherapy * Patient must capable of and provide study specific informed consent prior to study entry * BMI ≥21 * Weight ≥120lbs * No prior history of non-breast malignancies in the past 1 year unless it was a non- melanomatous skin lesion or carcinoma in situ of the cervix. * Patient must not have Acquired Immune Deficiency Syndrome (AIDS) or HIV positive based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS or HIV from this protocol is necessary because anti-retrovirals may alter patient metabolism. * Patient may not have any active Gastrointestinal/Malabsorption disorder at the discretion of the Principal Investigator which may include: * Chronic Pancreatitis * Chronic Diarrhea or Vomiting * Active Eating Disorder * No history of or current active drug/alcohol dependence. * No patients with decisional impairment. Exclusion Criteria: * Patient is male. * Age \<18 years * Clinical stage IV cancer * Inflammatory breast cancer (T4d) * Women of childbearing potential with a positive serum beta hCG. * Decision impaired patients. * BMI \< 21 * Weight \< 120lbs * Weight loss ≥10% in the last 3 mos * Prior invasive non-breast malignancy (except non-melanomatous skin cancer, carcinoma in situ of the cervix) unless disease free for a minimum of 1 year prior to registration * Non-epithelial breast malignancies such as sarcoma or lymphoma * Active Gastrointestinal/Malabsorption disorder at the discretion of the Principal -Investigator which may include: * Chronic Diarrhea or Vomiting * Active Eating Disorder * Active drug/alcohol dependence or abuse history.