A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea

Kyu Nam Park1,800 enrolled

Overview

Therapeutic hypothermia after out-of-hospital cardiac arrest is considered as a standard care. However, optimal candidates, optimal dose, duration, timing of initiation and rate of rewarming is still unknown. The objective of this project is to improve the outcomes for patients after resuscitation from out-of-hospital cardiac arrest treated with therapeutic hypothermia established from the analysis of multicenter registry data.

Study Type

OBSERVATIONAL

Enrollment

1,800

Conditions

Out-of-Hospital Cardiac Arrest

Interventions

not providedOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age of older than 18 years * out-of-hospital cardiac arrest * comatose mentality after return of spontaneous circulation (ROSC) * treated with therapeutic hypothermia, regardless of target temperature Exclusion Criteria: * suspected or confirmed to cerebrovascular accident * poor pre-arrest neurologic status (CPC\>3) * patients who are terminally ill or for whom intensive care dose not seem to be appropriate * Do not attempt resuscitation (DNAR) order * patients with tympanic membrane temperature below 30 degree celsius on admission

Locations (1)

Seoul St. Mary's Hospital, The Catholic University of Korea

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

survival

Time frame: 6 months after cardiac arrest

Neurologic Outcome

Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome

Time frame: 6 months after cardiac arrest

Neurologic Outcome

modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome

Time frame: after 6 months

Secondary Outcomes

survival

Time frame: duration of hospitalization, limit 180 days

neurological outcome

Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome

Time frame: duration of hospitalization, limit 180 days

neurological outcome

modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome

Time frame: duration of hospitalization, limit 180 days

Survival

Time frame: 1 month after cardiac arrest

neurological outcome

Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome

Time frame: 1 month after cardiac arrest

neurological outcome

modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome

Time frame: 1 month after cardiac arrest

Central Contacts

Kyu Nam Park, MD, PhD

CONTACT

82-2-2258-6301 emsky@catholic.ac.kr

Data from ClinicalTrials.gov

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