The Effect of Anesthetic Technique on VEGF-C and PGE2

General Hospital of Ningxia Medical University44 enrolled

Overview

The purpose of this study is to verify the effect of anesthetic technique on the change of postoperative serum vascular endothelial growth factor C and prostaglandin E2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

Uterine leiomyomas is the most common benign tumor of uterus, the most common tumor in women as well. Like many other forms of tumor, it requires an independent blood supply to enlarge. This process, angiogenesis, is mediated by vascular endothelial growth factor C (VEGF-C) and prostaglandin E2 (PGE2). Several studies have confirmed that VEGF-C has a high level in patients with uterine leiomyomas, which has also been demonstrated that it was related to occurrence and growth of uterine leiomyomas because it's capable of promoting angiogenesis, mitogenic, and vascular permeability-enhancing activities. Also, some researchers suggested that suppression of prostaglandin synthesis (including PGE2) via cyclooxygenase type-2 (COX-2) enzyme inhibition may reduce the incidence of some tumor. The aim of this study is to verify the effect of anesthetic technique on the change of postoperative serum VEGF-C and PGE2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Uterine Leiomyomas

Interventions

general anesthesia and patient controlled intravenous analgesiaOTHER

Patients receive general anesthesia intraoperative period and continuous intravenous analgesia postoperation

spinal anesthesia and continuous postoperative epidural analgesiaOTHER

Patients receive spinal anesthesia intraoperative period and continuous epidural analgesia postoperation

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients with leiomyomas requiring abdominal myomectomy, aged 18-65 year and American Society of Anesthesiologists (ASA) physical status I or II. Exclusion Criteria: * The patients who had a history of surgery within the preceding two weeks, a history of blood transfusion and a history of coronary artery disease, any contraindication to spinal anesthesia or opioid analgesia.

Outcomes

Primary Outcomes

Change of vascular endothelial growth factor C before anesthesia and at 48 hours after surgery

Blood samples were sampled before anesthesia and at 48h after surgery for the serum VEGF-C，which were analyzed by using enzyme linked immunosorbent assay (ELISA).

Time frame: Before anesthesia and at 48 hours after surgery

Change of prostaglandin E2 before anesthesia and at 48 hours after surgery

Blood samples were sampled before anesthesia and at 48h after surgery for the serum PGE2，which were analyzed by using enzyme linked immunosorbent assay (ELISA).

Time frame: Before anesthesia and at 48 hours after surgery

Secondary Outcomes

Visual analog scale (VAS) pain scores

Visual analog scale (VAS) pain scores were used to evaluate postoperative pain at 2h, 4h, 8h, 12h, 24h and 48h after surgery by the anesthetist

Time frame: at 2h, 4h, 8h, 12h, 24h and 48h after surgery

Data from ClinicalTrials.gov

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