Sickle cell disease (SCD) is an inherited disorder characterized by recurrent painful crises with ischemia resulting from vascular occlusion. Adults with SCD have increased arterial stiffness and reduced flow-mediated dilation (FMD), due to impaired release of substances such as nitric oxide. The present study assess the vascular properties of carotid and brachial arteries in children with SCD compared with a control group without cardiovascular risk factors.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
31
Measures by Doppler and study of endothelial function
University Hospital of Toulouse
Toulouse, France
Evaluation of endothelial function
Evaluation parameter of endothelial function (brachial artery): flow dependent dilatation (expressed in%)
Time frame: baseline
match the measurement thickness of the intima media
The thickness of the intima media (ITM) on the right common carotid
Time frame: baseline
match the measurement systolic and diastolic diameters
systolic and diastolic diameters (sD, dD)
Time frame: baseline
distensibility cross sectional
match the measurement on the compliance and distensibility cross sectional (CCS, DCS)
Time frame: baseline
Match the measurement on the diastolic wall stress
diastolic wall stress (DWS)
Time frame: baseline
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