Suicide is a major health problem that causes annually a million death worldwide. Loneliness is known to be associated with suicidal ideation in minors and to be related with suicidal risk in elderly people. However little is known about this association in a middle-aged population. Loneliness is a modifiable factor with suitable psychotherapeutic measures, it is essential to improve the scientific and medical knowledge about the link between this feeling and suicide risk in a population of depressed patients in middle age. The main objective is the study of the relationship between loneliness and the occurrence of suicidal behavior (SB) in major depressed adult population over 12 months. The secondary objectives are: * Identification of risk factors (clinical, neuropsychological and biological) of the occurrence of SB within a clinical population and their interaction; * Identification of predictive factors (clinical, neuropsychological, biological) therapeutic response to antidepressant in the context of depression.
This project is based on clinical, neuropsychological and biological data routinely collected in the Department of Emergency Psychiatry and Post Acute Care. This is a one year follow-up prospective study. Over three years, 600 depressed patients will be recruited. * First visit (inclusion): clinical, biological and neuropsychological assessment * Follow up visits (3, 6 and 12 months): clinical assessment only
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
600
Blood sample, clinical assessment with questionnaires
frequency of suicide attempts at one year
frequency of suicide attempts during the 12 months follow-up depending on the intensity of the feeling of loneliness evaluated by the loneliness scale of the University of Laval (ESUL)
Time frame: At 12 months
frequency of suicide attempts during the follow up
frequency of suicide attempts during the follow up
Time frame: At 3 and 6 months
comorbid psychiatric disorders of Axis I
comorbid psychiatric disorders of Axis I assessed by the Mini International Neuropsychiatric Interview (MINI)
Time frame: At the inclusion, 3, 6, and 12 months
intensity of the depression
intensity of the depression assessed by the physician with the Inventory of Depressive Symptomatology, clinician rating (IDSC-30) and with the Montgomery-Asberg depression rating scale (MADRS) and assessed by the patient with the Beck Depression Inventory (BDI) scale.
Time frame: At the inclusion, 3, 6, and 12 months
intensity of suicidal ideation
intensity of suicidal ideation assessed by visual analogic scale
Time frame: At the inclusion, 3, 6, and 12 months
features of suicidal behavior
Features of SB (number and methods of suicide attempts, nature of the precipitating factor, motivation, lethality, level of impulsiveness or premeditation) by the Columbia-Suicide Severity Rating Scale (CSSRS), the Risk Rescue Rating Scale (RRRS) and the Suicidal Intent Scales (SIS).
Time frame: At the inclusion, 3, 6, and 12 months
personal history of childhood abuse
personal history of childhood abuse assessed by the Childhood Trauma Questionnaire
Time frame: At the inclusion, 3, 6, and 12 months
intensity of psychological pain
intensity of psychological pain assessed by visual analogic scale
Time frame: At the inclusion, 3, 6, and 12 months
inflammatory markers
level of C protein reactive in a blood sample collected at inclusion
Time frame: At the inclusion, 3, 6, and 12 months
thyroid function
levels of thyroid-stimulating hormone (TSH), triiodothyronine(T3), and thyroxine(T4) in a blood sample collected at inclusion
Time frame: At the inclusion
lipid profile
level of cholesterol, triglycerides, phospholipids in a blood sample collected at inclusion
Time frame: At the inclusion
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