A prospective multicenter cohort study in 5 hospitals in Spain will be initiated in 2016. Objectives: 1. To estimate and describe patterns of multimorbidity and polypharmacy in patients over 64 admitted for a chronic disease exacerbation. 2. To analyze the potentially inappropriate prescribing (PPI) drugs according to STOPP / START (SS) criteria. 3. To evaluate the relationship between multimorbidity and PPI and adverse medication (RAM) preventable reaction. The cohort will include 800 patients \>64 years admitted in internal medicine and / or geriatric department of 5 hospitals of the National Health Service. Application of the SS criteria (released in 2015) on admission and at discharge, and collection of demographic and clinical variables including comorbidities, baseline chronic medication, geriatric syndromes, functional capacity and RAM. Descriptive analysis and bivariate parametric or nonparametric tests will be applied to analyze relationship between morbidity, polypharmacy, SS criteria and RAM. Intraobserver agreement will be assessed for SS criteria. Multiple regression techniques will be applied, where the dependent variable will be the PPI or the RAM.
Study Type
OBSERVATIONAL
Enrollment
740
Corporacio Parc Taulí
Sabadell, Spain
Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria
Time frame: At study entry
Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria
Time frame: Through study completion, an average of 2 years
Percentage of patients with polypharmacy
Polypharmacy=more than 5 chronic medications
Time frame: At study entry
Patients with any treatment-related adverse events (ADR), according to the Wills & Brown classification
Time frame: Through study completion, an average of 2 years
Percentage of different Patterns of multimorbidity in chronic patients, according to clusters or associations of different chronic conditions
Time frame: At study entry
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