Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases

Boston Children's Hospital59 enrolled

Overview

This is a pilot cross-sectional study of measured transcutaneous CO-oximetry in children with inflammatory and non-inflammatory conditions.

Children and young adults age 6-24 with the following conditions: asthma, pneumonia, allergic rhinitis, cystic fibrosis, and well child (without inflammatory illness) will be recruited. Subjects will be asked to complete a brief screening survey to determine if they meet inclusion criteria. Enrolled subjects will be asked to complete questionnaire forms to characterize their health, current symptoms, medications, and common exposures. Transcutaneous carboxyhemoglobin will be recorded. This study is cross-sectional and will only require one visit coinciding with the clinical visit. Analysis will determine the pairwise differences in SpCO between conditions tested.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Asthma Allergic Rhinitis Cystic Fibrosis Pneumonia

Eligibility

Sex: ALLMin age: 6 YearsMax age: 24 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of asthma, pneumonia, allergic rhinitis, or none of the previous (control group) * Ability to complete study procedures Exclusion Criteria: * Cardiopulmonary disease outside of the specific conditions for inclusion * Prematurity * Congenital heart disease * Current diagnosis of more than one of the following: asthma, pneumonia, allergic rhinitis, cystic fibrosis, or - for controls - any current infection * Recent serious bacterial infection (except for pneumonia in the pneumonia group) * Concurrent clinical chest X-ray with findings other those that expected for the group (i.e. normal chest X-ray in pneumonia group or suspected pneumonia on chest X-ray in asthma group). To be determined by attending radiologist's interpretation.

Locations (1)

Boston Children's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

SpCO comparison: uncontrolled asthma v. other groups

A pairwise comparison of mean SpCO will be performed between asthma exacerbation group and each other group, e.g., asthma exacerbation v. stable asthma, asthma exacerbation v. pneumonia, etc. An independent t-test will be used to determine statistical significance of the difference of means.

Time frame: Time of visit

Data from ClinicalTrials.gov

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