The purpose of this study is to determine whether regular dosage of paracetamol causes transaminitis (hepatitis) and evaluate its potency in the treatment of dengue infection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
123
Paracetamol 500 mg x 1 tablets according to patient's body weight
Placebo 500 mg x 1 tablets according to patient's body weight
Phramongkutklao College of Medicine and Hospital
Bangkok, Thailand
Fort Adisorn Hospital
Changwat Sara Buri, Thailand
Anandamahidol Hospital
Lopburi, Thailand
Proportion of subjects with abnormal serum transaminase levels on the last day of fever
Serum alanine transaminase and aspartate transaminase level will be measured at admission, and on every morning afterwards until the subject is discharged. The proportion of subjects with abnormal serum transaminase levels will be compared.
Time frame: Day 1-8
Mean serum transaminase level
Mean serum transaminase level will be compared.
Time frame: Day 1-8
Mean change in serum transaminase levels
The change in serum transaminase levels from baseline at admission will be compared.
Time frame: Day 1-8
Body temperature
Axillary temperature will be recorded every 4 hours until discharge or 8 days after admission, whichever comes first.
Time frame: 8 days
Duration of fever
Duration from the fever onset to the last febrile temperature will be compared.
Time frame: 8 days
Length of stay
Duration from hospital admission to discharge will be compared.
Time frame: 10 days
Number of drug tablet used
Number of drug tablet used will be compared, both paracetamol/placebo and tramadol.
Time frame: 8 days
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