Predicting Success of HFNC: The Utility of the ROX Index

Hospital Universitari Vall d'Hebron Research Institute201 enrolled

Overview

The purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with High Flow nasal cannula.

Purpose The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC). Materials and methods This is a 4-year prospective observational 2-center cohort study including patients with severe pneumonia treated with HFNC. High-flow nasal cannula failure was defined as need for MV. ROX index was defined as the ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate.

Study Type

OBSERVATIONAL

Enrollment

201

Conditions

Acute Respiratory Failure Pneumonia

Interventions

mechanical ventilationPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of acute respiratory failure secondary to pneumonia receiving HFNC therapy Exclusion Criteria: * younger than 18 years old * indication for mechanical ventilation at ICU admission * limitation of therapeutic effort

Outcomes

Primary Outcomes

prediction of need for mechanical ventilation using ROX index

participants will be followed during their stay in the ICU registering the days with HFNC treatment and their need or not for mechanical ventilation.

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

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