L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients

Inclusion Criteria: Patient must meet all of the following criteria: • Female patients with pathologically determined advanced (progressive disease or refractory to 3 cycles of standard chemotherapy) or metastatic (any line) triple negative breast cancer (TNBC). TNBC is defined as: Estrogen receptor negative and progesterone receptor negative (\<10% staining by immunohistochemistry \[IHC\]). Human epidermal growth factor receptor 2 (HER2) negative. HER2 negativity must be confirmed by one of the following: * Fluorescence in situ hybridization (FISH)-negative (FISH ratio \<2), or * IHC 0-1+, or * IHC 2+ AND FISH-negative (FISH ratio \<2). Eastern Cooperative Oncology Group performance status of ≤ 2 * Age ≥ 18 years * Laboratory values within the following ranges: * Hemoglobin ≥9.0 g/dL (transfusions permitted) * Absolute neutrophil count ≥1500/mm3 (1.5 x 109/L) * Platelet count ≥100,000/mm3 (100 x 109/L) * Total bilirubin \<2 X upper limit of normal (ULN) * Creatinine (Cr) \<2 X ULN and Cr clearance (CrCl) ≥30 by Cockcroft and Gault * Alanine transaminase (ALT) and aspartate transaminase (AST) \<2 X ULN (if liver metastases are present then ALT and AST must be \<5 X ULN) * Have adequate organ function (cardiac ejection fraction of ≥ 45%) * Negative serum pregnancy test within 7 days of the administration of the first treatment dose for women of childbearing potential (WOCBP). For WOCBP, adequate contraception must be used throughout the study. * Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments. * Patient must be willing to undergo biopsies as required by the study protocol. Biopsies will be based on acceptable clinical risks as judged by investigator. Tissue from a previous biopsy will be accepted in the form of tissue slides. Exclusion Criteria: History of poorly controlled hypertension (defined as systolic blood pressure \>150 mmHg at baseline) * Patients with metastatic disease who have received radiation therapy, chemotherapy, or non-cytotoxic investigational agents within 2 weeks of study treatment initiation. * Patients who received docetaxel at any line of treatment within the past 12 months * Evidence of New York Heart Association class III or greater cardiac disease * History of myocardial infarction, stroke, ventricular arrhythmia, or symptomatic conduction abnormality within the past 12 months * History of congenital QT prolongation * Absolute corrected QT interval of \>480 msec in the presence of potassium \>4.0 milliequivalent/L and magnesium \>1.8 mg/dL * Any medical or psychiatric condition that would prevent informed consent or limit expected survival to less than 4 weeks * Symptomatic central nervous system metastases * Pregnant or nursing women * Hypersensitivity or intolerance to L-NMMA, docetaxel, amlodipine, pegfilgrastim, or their components * Use of amlodipine or another calcium channel blocker in the past 14 days * Alcoholism or hepatic disease with the exception of liver metastases * Severe renal insufficiency (CrCl \<30 mL/min \[Cockcroft and Gault\]) * History of gastrointestinal bleeding, ulceration, or perforation * Concurrent use of potent cytochrome P450 (CYP)3A4 inhibitors * Concurrent use of potent CYP3A4 inducers * Concurrent use of medications that interact with nitrate/nitrites * Use of an investigational drug within 14 days preceding the first dose of study medication. * Concurrent use of any complementary or alternative medicines * Patients with \> Grade 2 neuropathy * Inability to take aspirin