Assess the accuracy of the sequential measurements by 3D Shear Wave Elastography (SWE) for predicting histological response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
140
Ultrasound imaging with Elastography will be performed at the inclusion (T0), after course 1 and course 2 respectively with anthracyclines, at the end of anthracycline treatment and at the end of taxane treatment.
Optional biopsy of breast tumor under neoadjuvant chemotherapy after the course 2 of anthracycline.
Institut Curie Paris
Paris, France
Assess the accuracy of the sequential measurements by 3D Shear Wave Elastography (SWE) for predicting histological response to neoadjuvant chemotherapy
Measure of the tumor prior to neoadjuvant chemotherapy (T0), at T1 and T2(1stand 2nd courses of anthracycline), at mid-treatment between anthracycline and taxane chemotherapy (Tmi), at the end of chemotherapy before surgery (Tfin).
Time frame: up to 32 months
Elastic properties before treatment (especially ratio between tumor and glandular breast or fat tissues close to the tumors)
Use technic Supersonic Shear Imaging.
Time frame: up to 32 months
peritumoral environmental elasticity properties
Use technic Supersonic Shear Imaging (Explorer, Supersonic Imagine).
Time frame: up to 32 months
Reliable early biomarker of histological response.
Estimate under chemotherapy if early changes in tumor's elasticity can provide a reliable early biomarker of histological response.
Time frame: up to 32 months
tumor volume changes under treatment by 3D ultrasound
Estimate tumor volume changes under treatment by 3D ultrasound and Compare with measurements obtained by other conventional imaging methods currently used for monitoring patients under neoadjuvant chemotherapy
Time frame: up to 32 months
Compare changes in tumor elasticity under chemotherapy to variables obtained by other imaging modalities (Breast MRI) performed in clinical routine
Time frame: up to 32 months
Compare changes in tumor elasticity under neoadjuvant chemotherapy to changes in diffusion apparent coefficient by using technic Supersonic Shear Imaging (Explorer, Supersonic Imagine).
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: up to 32 months
Compare changes in tumor volume to histological response (Gold Standard : surgery after neoadjuvant chemotherapy according to " Residual Cancer Burden " score
Time frame: up to 32 months
Compare predictive value (semi-quantitative et quantitative measurements) of tumor elasticity
Time frame: up to 32 months
Assess vascular shape and its evolution under treatment by Ultrasensitive Doppler technic "Ultra-Fast Doppler"
Time frame: up to 32 months
Compare tumor elasticity to conventional histological parameters
For the additional biopsy (optional) under neoadjuvant chemotherapy at T2, correlation elastography to pathological parameters of peritumoral environment by analyzing conventional histological parameters.
Time frame: 6 weeks