Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil

University Hospital, Toulouse20 enrolled

Overview

Hyperinflation Assessment After Treatment by Lung Volume Reduction Coil (HEAT-LVRC) on Hyperinflation in Severe Emphysema

Two sequences (around 30 minutes) are necessary by patient. Under general anesthesia, two lobs treatment ( 10 Coil by lob) successively introduced by a bronchoscope.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Emphysema

Interventions

BronchoscopyPROCEDURE

Two sequences of 30 minutes are necessary by patient

Lung Volume Reduction Coil (HEAT-LVRC)DEVICE

Bronchoscopy with Heat-LVRC

Eligibility

Sex: ALLMin age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Severe emphysema (recent CT-scan (\< 6 mois) ) * Age \> 35 ans * Modified Medical Research Council Scale (mMRC) \> 2 * Forced expiratory volume in one second (FEV1) post-bronchodilatator \< 45% * Residual volume \> 175% * Total Pulmonary capacity \> 100% Exclusion Criteria: * Forced expiratory volume in one second (FEV1) variability \> 20% after bronchodilatator * Carbon Monoxide Diffusing Capacity (TLCO) \< 20% * Recurrent respiratory infection Infections with clinics symptoms * Pulmonary arterial hypertension (PAH) with Pulmonary Arterial Systolic Pressure (PAPS) estimated with echography \> 50 mm Hg * Impossibility to walk more that 140 meter (6 min test) * Surgery history of volume reduction or pulmonary transplantation * Broncho-dilatation with clinic symptoms

Locations (1)

Larrey Hospital

Toulouse, France

Outcomes

Primary Outcomes

Hyperinflation Assessment After Treatment

Assessed by Lung Volume Reduction Coil

Time frame: 3 months

Data from ClinicalTrials.gov

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